There aren't many configuration options for EasyLayouts - the following explains these.
You should become familiar with EasyLayouts and creating Layouts before you go through these configuration options in detail since some will only make sense when you understand how to use EasyLayouts.
EasyLayouts supports Joomla! Versioning so when you enable this option you can roll back changes you have made in your layouts to an earlier version if you make a mistake or don't like the changes you made. See https://docs.joomla.org/Help37:Components_Version_History for more information about Joomla! versioning
This is an option for advanced users that allows you to create layouts where Joomla access level members are blocked from using the layout - where Joomla normally allows access level members to use a layout. See the article on Layout Options that explains how this feature works in detail and where it may be useful.
See the article on keeping EasyLayouts Up To Date.
These control the default settings that are in place when you create new layouts
These are the normal Joomla access control settings for the users on your site that control their interaction with EasyLayouts in the backend of Joomla!.